Pyrrole alkaloids from the fruits of Morus alba

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5656-5659. doi: 10.1016/j.bmcl.2014.10.073. Epub 2014 Oct 29.

Abstract

Phytochemical investigation of the fruits of Morus alba afforded seventeen pyrrole alkaloids including five new compounds. The structures of five new pyrrole alkaloids, named morroles B-F (4, 5, 7, 16 and 17), were determined on the basis of spectroscopic interpretations. 4-[Formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl]butanoate (2) was synthesized by chemical reaction but first isolated from nature. Among isolated compounds, compounds 6 and 14 significantly inhibited pancreatic lipase activity.

Keywords: Moraceae; Morroles B–F; Morus alba; Mulberry; Pancreatic lipase; Pyrrole alkaloids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Alkaloids / pharmacology
  • Animals
  • Fruit / chemistry*
  • Lipase / antagonists & inhibitors*
  • Molecular Structure
  • Morus / chemistry*
  • Nuclear Magnetic Resonance, Biomolecular
  • Pancreas / drug effects
  • Pancreas / enzymology*
  • Pyrroles / chemistry
  • Pyrroles / isolation & purification*
  • Pyrroles / pharmacology
  • Swine

Substances

  • Alkaloids
  • Pyrroles
  • Lipase
  • PNLIP protein, human