Abstract
A few naturally occurring N(6)-substituted adenosine derivatives (cytokinin ribosides) were investigated as inhibitors of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 μM). A docking study suggests that anti-aggregation activity of these compounds could involve an interaction with the P2Y12 receptor binding site.
Keywords:
Anti-aggregation activity; Cytokinin ribosides; Homology modeling; Molecular docking; P2Y(12) receptor; Platelets.
Copyright © 2014 Elsevier Ltd. All rights reserved.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Adenosine / chemistry
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Adenosine / metabolism
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Adenosine Diphosphate / metabolism
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Blood Platelets / cytology*
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Blood Platelets / metabolism*
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Cytokinins / chemistry
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Cytokinins / metabolism*
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Humans
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In Vitro Techniques
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Plant Growth Regulators / chemistry
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Plant Growth Regulators / metabolism
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Platelet Aggregation / drug effects*
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Platelet Aggregation Inhibitors / pharmacology*
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Purinergic P1 Receptor Agonists / chemistry
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Purinergic P1 Receptor Agonists / metabolism
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Receptors, Purinergic P2Y12 / metabolism*
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Ribonucleosides / chemistry
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Ribonucleosides / metabolism*
Substances
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Cytokinins
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Plant Growth Regulators
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Platelet Aggregation Inhibitors
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Purinergic P1 Receptor Agonists
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Receptors, Purinergic P2Y12
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Ribonucleosides
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Adenosine Diphosphate
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Adenosine