Naturally occurring N(6)-substituted adenosines (cytokinin ribosides) are in vitro inhibitors of platelet aggregation: an in silico evaluation of their interaction with the P2Y(12) receptor

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5652-5655. doi: 10.1016/j.bmcl.2014.10.080. Epub 2014 Oct 30.

Abstract

A few naturally occurring N(6)-substituted adenosine derivatives (cytokinin ribosides) were investigated as inhibitors of platelet aggregation induced in vitro by collagen and their activity range was demonstrated (IC50: 6.77-141 μM). A docking study suggests that anti-aggregation activity of these compounds could involve an interaction with the P2Y12 receptor binding site.

Keywords: Anti-aggregation activity; Cytokinin ribosides; Homology modeling; Molecular docking; P2Y(12) receptor; Platelets.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / chemistry
  • Adenosine / metabolism
  • Adenosine Diphosphate / metabolism
  • Blood Platelets / cytology*
  • Blood Platelets / metabolism*
  • Cytokinins / chemistry
  • Cytokinins / metabolism*
  • Humans
  • In Vitro Techniques
  • Plant Growth Regulators / chemistry
  • Plant Growth Regulators / metabolism
  • Platelet Aggregation / drug effects*
  • Platelet Aggregation Inhibitors / pharmacology*
  • Purinergic P1 Receptor Agonists / chemistry
  • Purinergic P1 Receptor Agonists / metabolism
  • Receptors, Purinergic P2Y12 / metabolism*
  • Ribonucleosides / chemistry
  • Ribonucleosides / metabolism*

Substances

  • Cytokinins
  • Plant Growth Regulators
  • Platelet Aggregation Inhibitors
  • Purinergic P1 Receptor Agonists
  • Receptors, Purinergic P2Y12
  • Ribonucleosides
  • Adenosine Diphosphate
  • Adenosine