Comparison of drug-eluting balloon versus drug-eluting stent in patients with in-stent restenosis: insight from randomized controlled trials

Wahafu Mamuti; Alimjan Ablimit; Wumaierjiang Kelimu; Fang Rao; Abulimiti Jiamali; Wei Zhang; Xiaoli Pei; Feng Zhang

doi:10.1016/j.ijcard.2014.11.114

Comparison of drug-eluting balloon versus drug-eluting stent in patients with in-stent restenosis: insight from randomized controlled trials

Int J Cardiol. 2015 Jan 20:179:424-9. doi: 10.1016/j.ijcard.2014.11.114. Epub 2014 Nov 18.

Authors

Wahafu Mamuti¹, Alimjan Ablimit¹, Wumaierjiang Kelimu¹, Fang Rao¹, Abulimiti Jiamali¹, Wei Zhang¹, Xiaoli Pei¹, Feng Zhang²

Affiliations

¹ Department of Cardiology, Kashgar Prefecture Second People's Hospital, Kashi, Xinjiang 844000, China.
² Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Electronic address: zhang.feng@zs-hospital.sh.cn.

PMID: 25465304
DOI: 10.1016/j.ijcard.2014.11.114

Abstract

Backgrounds: In-stent restenosis (ISR) remains an important issue even in the current drug-eluting stent (DES) era. We performed a meta-analysis to assess the clinical efficacy and safety of drug-eluting balloon (DEB) as compared with DES for the treatment of ISR.

Methods: The published literature was scanned by formal searches of electronic databases from January 2005 to February 2014. All randomized controlled trials were eligible for inclusion if they compared DEB with DES in patients with ISR.

Results: Prespecified criteria were met by 4 trials involving 803 patients. There was no significant difference in the primary endpoint (12-month major adverse cardiac events) between the 2 groups (risk ratio [RR] 1.04, P=0.80). The incidence of death (RR 0.81, P=0.62), myocardial infarction (RR 0.66, P=0.29), and target lesion revascularization (RR 1.35, P=0.12) in the DEB group was also similar to those in the DES group.

Conclusions: This meta-analysis showed that DEB was associated with comparable clinical outcomes to DES for the treatment of ISR. DEB might be the preferred interventional strategy for patients with ISR by obviating the need of additional stent layer.

Keywords: Coronary artery disease; Drug-eluting balloon; Drug-eluting stent; In-stent restenosis.

Publication types

Comparative Study
Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Angioplasty, Balloon, Coronary*
Coronary Restenosis / therapy*
Drug-Eluting Stents*
Humans
Randomized Controlled Trials as Topic
Treatment Outcome