Beyond autonomic neuromodulation: acetylcholinesterase inhibitor against peripheral artery disease

Int J Cardiol. 2015 Jan 15:178:253-5. doi: 10.1016/j.ijcard.2014.10.048. Epub 2014 Oct 22.

Abstract

The acetylcholinesterase inhibitor (AChEI)-based therapeutic strategies have been shown to have vasculoprotective properties in the animal model of hindlimb ischemia due to its activation of the endothelial cholinergic system. However, little is know about whether other cell types (myocytes, immunocytes) are involved in the AChEI-related therapeutic benefits in peripheral artery disease. Therefore, we review the multiple cell-targeted effects of AChEI on the animal model of hindlimb ischemia and explore its clinical application in angiomyogenesis.

Keywords: Acetylcholinesterase inhibitor; Angiomyogenesis; Peripheral artery disease.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Autonomic Nervous System / drug effects
  • Autonomic Nervous System / physiology
  • Cell Survival / drug effects
  • Cell Survival / physiology
  • Cholinesterase Inhibitors / pharmacology
  • Cholinesterase Inhibitors / therapeutic use*
  • Humans
  • Peripheral Arterial Disease / diagnosis
  • Peripheral Arterial Disease / drug therapy*
  • Peripheral Arterial Disease / enzymology

Substances

  • Cholinesterase Inhibitors