Structure-activity relationships in new polycationic molecules based on two 1,4-diazabicyclo[2.2.2]octanes as artificial ribonucleases

E Burakova; N Kovalev; M Zenkova; V Vlassov; V Silnikov

doi:10.1016/j.bioorg.2014.10.002

Structure-activity relationships in new polycationic molecules based on two 1,4-diazabicyclo[2.2.2]octanes as artificial ribonucleases

Bioorg Chem. 2014 Dec:57:127-131. doi: 10.1016/j.bioorg.2014.10.002. Epub 2014 Oct 24.

Authors

E Burakova¹, N Kovalev², M Zenkova², V Vlassov², V Silnikov²

Affiliations

¹ Institute of Chemical Biology and Fundamental Medicine, Lavrentiev Ave., 8, Novosibirsk 630090, Russia. Electronic address: kat7@ngs.ru.
² Institute of Chemical Biology and Fundamental Medicine, Lavrentiev Ave., 8, Novosibirsk 630090, Russia.

PMID: 25462988
DOI: 10.1016/j.bioorg.2014.10.002

Abstract

In the present study, we designed and synthesised new polycationic molecules based on two 1,4-diazabicyclo[2.2.2]octane (DABCO) moieties with hydrophobic groups connected by different linkers. The structure and the RNA-cleavage activity relationships of this novel series of artificial ribonucleases (aRNases) were investigated.

Keywords: Artificial ribonucleases; Lipophilicity; Phosphodiester bond cleavage; RNA.

MeSH terms

Piperazines / chemical synthesis
Piperazines / chemistry*
Piperazines / pharmacology*
Polyamines / chemical synthesis
Polyamines / chemistry
Polyamines / pharmacology
Polyelectrolytes
RNA / metabolism*
Ribonucleases / chemistry*
Structure-Activity Relationship

Substances

Piperazines
Polyamines
Polyelectrolytes
polycations
RNA
Ribonucleases
triethylenediamine