Legionella pneumophila: homeward bound away from the phagosome

Akriti Prashar; Mauricio R Terebiznik

doi:10.1016/j.mib.2014.11.008

Legionella pneumophila: homeward bound away from the phagosome

Curr Opin Microbiol. 2015 Feb:23:86-93. doi: 10.1016/j.mib.2014.11.008. Epub 2014 Nov 27.

Authors

Akriti Prashar¹, Mauricio R Terebiznik²

Affiliations

¹ Biological Sciences, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4; Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5.
² Biological Sciences, University of Toronto at Scarborough, 1265 Military Trail, Scarborough, Ontario, Canada M1C 1A4; Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, Canada M5S 3G5. Electronic address: terebiznik@utsc.utoronto.ca.

PMID: 25461578
DOI: 10.1016/j.mib.2014.11.008

Abstract

The intracellular pathogen Legionella pneumophila (Lp) survives and replicates inside a specialized vacuolar compartment that evades canonical phagosomal maturation. Through the action of a large number of effectors translocated into the host cytosol via the Dot/Icm type IV secretion system, Lp subverts host cell pathways to convert its nascent phagosome into an ER-derived compartment, the Legionella containing vacuole (LCV), which serves as bacterial replication niche.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Bacterial Proteins / metabolism*
Bacterial Secretion Systems
Cell Physiological Phenomena / drug effects*
Endosomes / microbiology*
Host-Pathogen Interactions*
Humans
Immune Evasion
Legionella pneumophila / immunology
Legionella pneumophila / physiology*
Phagosomes / microbiology*
Protein Transport
Virulence Factors / metabolism*

Substances

Bacterial Proteins
Bacterial Secretion Systems
Virulence Factors