Novel receptors for bacterial protein toxins

Gudula Schmidt; Panagiotis Papatheodorou; Klaus Aktories

doi:10.1016/j.mib.2014.11.003

Novel receptors for bacterial protein toxins

Curr Opin Microbiol. 2015 Feb:23:55-61. doi: 10.1016/j.mib.2014.11.003. Epub 2014 Nov 22.

Authors

Gudula Schmidt¹, Panagiotis Papatheodorou¹, Klaus Aktories²

Affiliations

¹ Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Albert-Ludwigs-Universität Freiburg, Albert-Str. 25, 79104 Freiburg, Germany.
² Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Albert-Ludwigs-Universität Freiburg, Albert-Str. 25, 79104 Freiburg, Germany; Centre for Biological Signalling Studies (BIOSS), Germany. Electronic address: klaus.aktories@pharmakol.uni-freiburg.de.

PMID: 25461573
DOI: 10.1016/j.mib.2014.11.003

Abstract

While bacterial effectors are often directly introduced into eukaryotic target cells by various types of injection machines, toxins enter the cytosol of host cells from endosomal compartments or after retrograde transport via Golgi from the ER. A first crucial step of toxin-host interaction is receptor binding. Using optimized protocols and new methods novel toxin receptors have been identified, including metalloprotease ADAM 10 for Staphylococcus aureus α-toxin, laminin receptor Lu/BCAM for Escherichia coli cytotoxic necrotizing factor CNF1, lipolysis stimulated lipoprotein receptor (LSR) for Clostridium difficile transferase CDT and low-density lipoprotein receptor-related protein (LRP) 1 for Clostridium perfringens TpeL toxin.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bacterial Proteins / metabolism*
Bacterial Toxins / metabolism*
Protein Binding
Protein Transport

Substances

Bacterial Proteins
Bacterial Toxins