Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress

Csaba Hegedűs; László Virág

doi:10.1016/j.redox.2014.08.003

Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress

Redox Biol. 2014:2:978-82. doi: 10.1016/j.redox.2014.08.003. Epub 2014 Aug 21.

Authors

Csaba Hegedűs¹, László Virág²

Affiliations

¹ Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Nagyerdei Krt. 98., H-4032 Debrecen, Hungary.
² Department of Medical Chemistry, Faculty of Medicine, University of Debrecen, Nagyerdei Krt. 98., H-4032 Debrecen, Hungary; MTA-DE Cell Biology and Signaling Research Group, Debrecen, Hungary. Electronic address: lvirag@med.unideb.hu.

Abstract

Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family. PARP-1 modifies target proteins by attaching to them several NAD-derived ADP-ribose units forming poly(ADP-ribose) (PAR) polymers. PARylation controls many cellular processes while intense PARylation may also lead to cell death by various mechanisms. Here we summarize the modes of activation, inhibitors and modulators of PARP-1 and review the cellular functions regulated by the enzyme.

Keywords: Apoptosis; Cell death; Necroptosis; Oxidative stress; PARP1; Poly(ADP-ribosyl)ation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Humans
Oxidative Stress / drug effects
Oxidative Stress / physiology*
Poly (ADP-Ribose) Polymerase-1 / antagonists & inhibitors
Poly (ADP-Ribose) Polymerase-1 / metabolism*
Poly ADP Ribosylation / drug effects
Poly ADP Ribosylation / physiology*
Poly Adenosine Diphosphate Ribose / metabolism*

Substances

Poly Adenosine Diphosphate Ribose
PARP1 protein, human
Poly (ADP-Ribose) Polymerase-1