Pathophysiological mechanisms regulated by cytokines in gliomas

Anthos Christofides; Marinos Kosmopoulos; Christina Piperi

doi:10.1016/j.cyto.2014.09.008

Pathophysiological mechanisms regulated by cytokines in gliomas

Cytokine. 2015 Feb;71(2):377-84. doi: 10.1016/j.cyto.2014.09.008. Epub 2014 Nov 4.

Authors

Anthos Christofides¹, Marinos Kosmopoulos¹, Christina Piperi²

Affiliations

¹ Department of Biological Chemistry, University of Athens, Medical School, 11527 Athens, Greece.
² Department of Biological Chemistry, University of Athens, Medical School, 11527 Athens, Greece. Electronic address: cpiperi@med.uoa.gr.

PMID: 25458967
DOI: 10.1016/j.cyto.2014.09.008

Abstract

Glioma, a neuroglia originated malignancy, consists of one of the most aggressive primary tumors of the central nervous system with poor prognosis and lack of efficient treatment strategy. Cytokines have been implicated in several stages of glioma progression, participating in tumor onset, growth enhancement, angiogenesis and aggressiveness. Interestingly, cytokines have also the ability to inhibit glioma growth upon specific regulation or interplay with other molecules. This review addresses the dual role of major cytokines implicated in glioma pathology, pointing toward promising therapeutic approaches.

Keywords: Cytokines; Glioma; IL-18; TGF-β; TNF.

Publication types

Review

MeSH terms

Animals
Apoptosis
Biomarkers / metabolism
Brain Neoplasms / physiopathology*
Cytokines / metabolism*
Disease Progression
Epigenesis, Genetic
Gene Expression Regulation
Gene Expression Regulation, Neoplastic*
Genetic Therapy / methods
Glioma / physiopathology*
Humans
Interleukin-18 / metabolism*
Interleukin-1beta / metabolism
Interleukin-6 / metabolism
Interleukin-8 / metabolism
Microglia / pathology
Neovascularization, Pathologic
Prognosis
Transforming Growth Factor beta / metabolism

Substances

Biomarkers
Cytokines
Interleukin-18
Interleukin-1beta
Interleukin-6
Interleukin-8
Transforming Growth Factor beta