Chemical cryptology of cancer's histone code

Rhushikesh A Kulkarni; Jordan L Meier

doi:10.1016/j.chembiol.2014.11.003

Chemical cryptology of cancer's histone code

Chem Biol. 2014 Nov 20;21(11):1419-21. doi: 10.1016/j.chembiol.2014.11.003. Epub 2014 Nov 20.

Authors

Rhushikesh A Kulkarni¹, Jordan L Meier²

Affiliations

¹ Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
² Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: jordan.meier@nih.gov.

Abstract

Somatic mutations in non-Hodgkin's lymphoma frequently activate EZH2, a protein methyltransferase responsible for H3K27 trimethylation. In this issue of Chemistry and Biology, Bradley and coworkers describe a new set of EZH2 inhibitors amenable to probing the targetable role of H3K27 trimethylation in lymphoma.

Publication types

Comment

MeSH terms

Animals
Apoptosis / drug effects*
Enzyme Inhibitors / toxicity*
Histones / metabolism*
Humans
Polycomb Repressive Complex 2 / antagonists & inhibitors*
Small Molecule Libraries / toxicity*

Substances

Enzyme Inhibitors
Histones
Small Molecule Libraries
Polycomb Repressive Complex 2

Grants and funding

ZIA BC011488-02/Intramural NIH HHS/United States