The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease

Simon Chiu; Michel A Woodbury-Fariña; Mujeeb U Shad; Mariwan Husni; John Copen; Yves Bureau; Zack Cernovsky; J Jurui Hou; Hana Raheb; Kristen Terpstra; Veronica Sanchez; Ana Hategan; Mike Kaushal; Robbie Campbell

doi:10.1016/j.psc.2014.09.001

The role of nutrient-based epigenetic changes in buffering against stress, aging, and Alzheimer's disease

Psychiatr Clin North Am. 2014 Dec;37(4):591-623. doi: 10.1016/j.psc.2014.09.001. Epub 2014 Nov 25.

Authors

Simon Chiu¹, Michel A Woodbury-Fariña², Mujeeb U Shad³, Mariwan Husni⁴, John Copen⁵, Yves Bureau⁶, Zack Cernovsky⁷, J Jurui Hou⁸, Hana Raheb⁸, Kristen Terpstra⁹, Veronica Sanchez¹⁰, Ana Hategan¹¹, Mike Kaushal⁸, Robbie Campbell¹²

Affiliations

¹ Department of Psychiatry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6G 4X8, Canada. Electronic address: schiu3207@rogers.com.
² Department of Psychiatry, University of Puerto Rico School of Medicine, 307 Calle Eleonor Roosevelt, San Juan, PR 00918-2720, USA.
³ Oregon Health & Science University, Department Psychiatry, 3181 South West Sam Jackson Park Road, Portland, OR 97239-3098, USA.
⁴ Northern Ontario Medical School/Lakehead University, 955 Oliver Road, Thunder Bay, ON P7B 5E1, Canada; Faculty of Medicine, Imperial College London, London SW7 2AZ, UK.
⁵ Vancouver Island Health Authority, Department of Psychiatry, Victoria, BC, University of British Columbia-Victoria Medical Campus, Island Medical Program, University of Victoria, 3800 Finnerty Road, Victoria, BC V8N-1M5, Canada.
⁶ Department of Medical Biophysics, Schulich School of Medicine & Dentistry University of Western Ontario, London, ON N6G 4X8, Canada.
⁷ Certificate Professional Qualification (CPQ), Clinical Psychology, Association of State and Provincial Psychology Board (ASPB): USA and Canada.
⁸ Epigenetics Research Group, Lawson Health Research Institute, St Joseph Health Care, 268 Grosvenor Street, London, ON N6A 4V2, Canada.
⁹ Accelerated B.Sc.N. Nursing Program, Lawrence S. Bloomberg, Faculty of Nursing, University of Toronto, 155 College Street, Suite 130 Toronto, ON M5T 1P8, Canada.
¹⁰ McGill University, Meakins-Christie Labs, 3626 St., Urbain Street, Montreal, QC H2X 2P2, Canada.
¹¹ Geriatric Psychiatry Division, St. Joseph's Healthcare Hamilton /McMaster University Health Sciences, West 5th Campus 100 West 5th Hamilton, ON L8N 3K7, Canada.
¹² Department of Psychiatry, Schulich School of Medicine & Dentistry, The University of Western Ontario, London, ON N6G 4X8, Canada.

PMID: 25455068
DOI: 10.1016/j.psc.2014.09.001

Abstract

Converging evidence identifies stress-related disorders as putative risk factors for Alzheimer Disease (AD). This article reviews evidence on the complex interplay of stress, aging, and genes-epigenetics interactions. The recent classification of AD into preclinical, mild cognitive impairment, and AD offers a window for intervention to prevent, delay, or modify the course of AD. Evidence in support of the cognitive effects of epigenetics-diet, and nutraceuticals is reviewed. A proactive epigenetics diet and nutraceuticals program holds promise as potential buffer against the negative impact of aging and stress responses on cognition, and can optimize vascular, metabolic, and brain health in the community.

Keywords: Alzheimer dementia; Cognition; Epigenetics diet; Nutraceuticals; Stress.

Publication types

Review

MeSH terms

Aging / genetics*
Alzheimer Disease / complications
Alzheimer Disease / genetics*
Alzheimer Disease / physiopathology
Diet / methods*
Epigenesis, Genetic / genetics*
Humans
Risk Factors
Stress, Psychological / complications
Stress, Psychological / genetics*
Stress, Psychological / physiopathology