Regenerative medicine for the treatment of reproductive system disorders: current and potential options

Hooman Sadri-Ardekani; Anthony Atala

doi:10.1016/j.addr.2014.10.019

Regenerative medicine for the treatment of reproductive system disorders: current and potential options

Adv Drug Deliv Rev. 2015 Mar:82-83:145-52. doi: 10.1016/j.addr.2014.10.019. Epub 2014 Oct 23.

Authors

Hooman Sadri-Ardekani¹, Anthony Atala²

Affiliations

¹ Wake Forest Institute for Regenerative Medicine (WFIRM), Wake Forest School of Medicine, Winston-Salem, NC, USA; Department of Urology, Wake Forest School of Medicine, Winston-Salem, NC, USA. Electronic address: hsadri@wakehealth.edu.
² Wake Forest Institute for Regenerative Medicine (WFIRM), Wake Forest School of Medicine, Winston-Salem, NC, USA; Department of Urology, Wake Forest School of Medicine, Winston-Salem, NC, USA.

PMID: 25453265
DOI: 10.1016/j.addr.2014.10.019

Abstract

Regenerative medicine has opened new avenues for treating patients with severe reproductive system disorders, such as congenital abnormalities, cancer, trauma, infection, inflammation and iatrogenic injuries. Over the past two decades, scientists have advanced the field of reproductive tissue engineering to restore normal sexual function and preserve fertility in both female and male patients. In this review, we summarize recent advances in the use of cell, tissue, and organ-based regenerative medicine strategies for clinical application in reproductive system disorders.

Keywords: Female; Male; Regenerative medicine; Reproductive medicine; Tissue engineering.

Publication types

Review

MeSH terms

Biocompatible Materials / therapeutic use*
Genitalia / surgery*
Humans
Infertility / surgery*
Regenerative Medicine / methods*
Sexual Dysfunction, Physiological / therapy*
Stem Cell Transplantation / methods
Tissue Engineering / methods*

Substances

Biocompatible Materials