Arginase in the vascular endothelium: friend or foe?

Rudolf Lucas; David Fulton; Robert William Caldwell; Maritza J Romero

doi:10.3389/fimmu.2014.00589

Arginase in the vascular endothelium: friend or foe?

Front Immunol. 2014 Nov 17:5:589. doi: 10.3389/fimmu.2014.00589. eCollection 2014.

Authors

Rudolf Lucas¹, David Fulton¹, Robert William Caldwell², Maritza J Romero¹

Affiliations

¹ Vascular Biology Center, Medical College of Georgia, Georgia Regents University , Augusta, GA , USA ; Department of Pharmacology and Toxicology, Medical College of Georgia, Georgia Regents University , Augusta, GA , USA.
² Department of Pharmacology and Toxicology, Medical College of Georgia, Georgia Regents University , Augusta, GA , USA.

No abstract available

Keywords: arginase inhibitors; eNOS; impaired vasorelaxation; l-citrulline; microvascular permeability; reactive oxygen species; vessel wall remodeling.

Grants and funding

P01 HL101902/HL/NHLBI NIH HHS/United States