Auditory selective attention in adolescents with major depression: An event-related potential study

E Greimel; M Trinkl; J Bartling; S Bakos; N Grossheinrich; G Schulte-Körne

doi:10.1016/j.jad.2014.10.022

Auditory selective attention in adolescents with major depression: An event-related potential study

J Affect Disord. 2015 Feb 1:172:445-52. doi: 10.1016/j.jad.2014.10.022. Epub 2014 Oct 22.

Authors

E Greimel¹, M Trinkl², J Bartling², S Bakos², N Grossheinrich³, G Schulte-Körne²

Affiliations

¹ Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Pettenkoferstraße 8a, D-80336 Munich, Germany. Electronic address: Ellen.Greimel@med.uni-muenchen.de.
² Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Pettenkoferstraße 8a, D-80336 Munich, Germany.
³ Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Munich, Pettenkoferstraße 8a, D-80336 Munich, Germany; Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of the RWTH Aachen, Aachen, Germany; Translational Brain Medicine in Psychiatry and Neurology, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital of the RWTH Aachen/JARA Brain Translational Medicine, Aachen and Juelich, Germany.

PMID: 25451449
DOI: 10.1016/j.jad.2014.10.022

Abstract

Background: Major depression (MD) is associated with deficits in selective attention. Previous studies in adults with MD using event-related potentials (ERPs) reported abnormalities in the neurophysiological correlates of auditory selective attention. However, it is yet unclear whether these findings can be generalized to MD in adolescence. Thus, the aim of the present ERP study was to explore the neural mechanisms of auditory selective attention in adolescents with MD.

Methods: 24 male and female unmedicated adolescents with MD and 21 control subjects were included in the study. ERPs were collected during an auditory oddball paradigm.

Results: Depressive adolescents tended to show a longer N100 latency to target and non-target tones. Moreover, MD subjects showed a prolonged latency of the P200 component to targets. Across groups, longer P200 latency was associated with a decreased tendency of disinhibited behavior as assessed by a behavioral questionnaire.

Limitations: To be able to draw more precise conclusions about differences between the neural bases of selective attention in adolescents vs. adults with MD, future studies should include both age groups and apply the same experimental setting across all subjects.

Conclusions: The study provides strong support for abnormalities in the neurophysiolgical bases of selective attention in adolecents with MD at early stages of auditory information processing. Absent group differences in later ERP components reflecting voluntary attentional processes stand in contrast to results reported in adults with MD and may suggest that adolescents with MD possess mechanisms to compensate for abnormalities in the early stages of selective attention.

Keywords: Adolescence; Attention; Auditory oddball; Depression; Event-related potentials.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Attention* / physiology
Depressive Disorder, Major / physiopathology*
Depressive Disorder, Major / psychology*
Evoked Potentials, Auditory*
Female
Humans
Male