Recent advances in microbial production of fuels and chemicals using tools and strategies of systems metabolic engineering

Changhee Cho; So Young Choi; Zi Wei Luo; Sang Yup Lee

doi:10.1016/j.biotechadv.2014.11.006

Recent advances in microbial production of fuels and chemicals using tools and strategies of systems metabolic engineering

Biotechnol Adv. 2015 Nov 15;33(7):1455-66. doi: 10.1016/j.biotechadv.2014.11.006. Epub 2014 Nov 18.

Authors

Changhee Cho¹, So Young Choi¹, Zi Wei Luo¹, Sang Yup Lee²

Affiliations

¹ Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea; Center for Systems and Synthetic Biotechnology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea; Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea.
² Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea; Center for Systems and Synthetic Biotechnology, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea; Institute for the BioCentury, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Republic of Korea; BioInformatics Research Center, KAIST, Daejeon 305-701, Republic of Korea; BioProcess Engineering Research Center, KAIST, Daejeon 305-701, Republic of Korea; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm, Denmark. Electronic address: leesy@kaist.ac.kr.

PMID: 25450194
DOI: 10.1016/j.biotechadv.2014.11.006

Abstract

The advent of various systems metabolic engineering tools and strategies has enabled more sophisticated engineering of microorganisms for the production of industrially useful fuels and chemicals. Advances in systems metabolic engineering have been made in overproducing natural chemicals and producing novel non-natural chemicals. In this paper, we review the tools and strategies of systems metabolic engineering employed for the development of microorganisms for the production of various industrially useful chemicals belonging to fuels, building block chemicals, and specialty chemicals, in particular focusing on those reported in the last three years. It was aimed at providing the current landscape of systems metabolic engineering and suggesting directions to address future challenges towards successfully establishing processes for the bio-based production of fuels and chemicals from renewable resources.

Keywords: Building block chemicals; Fuels; Specialty chemicals; Systems metabolic engineering.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Industrial Microbiology*
Metabolic Engineering*
Systems Biology*