A review of biotransformation and pharmacology of ginsenoside compound K

Xi-Ding Yang; Yong-Yu Yang; Dong-Sheng Ouyang; Guo-Ping Yang

doi:10.1016/j.fitote.2014.11.019

A review of biotransformation and pharmacology of ginsenoside compound K

Fitoterapia. 2015 Jan:100:208-20. doi: 10.1016/j.fitote.2014.11.019. Epub 2014 Nov 28.

Authors

Xi-Ding Yang¹, Yong-Yu Yang², Dong-Sheng Ouyang³, Guo-Ping Yang⁴

Affiliations

¹ Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha 410013, China; School of Pharmaceutical Science, Central South University, Changsha 410013, China.
² School of Pharmaceutical Science, Central South University, Changsha 410013, China.
³ Institute of Clinical Pharmacology, Central South University, Changsha 410078, China.
⁴ Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha 410013, China. Electronic address: ygp9880@126.com.

PMID: 25449425
DOI: 10.1016/j.fitote.2014.11.019

Abstract

As an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, ginsenoside compound K (20-O-beta-d-glucopyranosyl-20(S)-protopanaxadiol, CK) is a major deglycosylated metabolite form of ginsenosides which is absorbed into the systemic circulation. And it has demonstrated such diverse intriguing biological properties as anticarcinogenic, anti-inflammation, antiallergic, anti-diabetic, anti-angiogenesis, anti-aging, neuroprotective and hepatoprotective effects. The present review shall summarize recent studies on various biotransformation and pharmacological activities of CK.

Keywords: Biotransformation; Ginseng; Ginsenoside compound K; Pharmacological activities.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biotransformation
Ginsenosides / metabolism*
Ginsenosides / pharmacology*

Substances

Ginsenosides
ginsenoside M1