Role of miRNAs in endometrial cancer

Shuangdi Li; Jiarong Zhang; Xiaoping Wan

doi:10.14670/HH-30.539

Role of miRNAs in endometrial cancer

Histol Histopathol. 2015 May;30(5):539-48. doi: 10.14670/HH-30.539. Epub 2014 Nov 26.

Authors

Shuangdi Li¹, Jiarong Zhang², Xiaoping Wan³

Affiliations

¹ Department of Obstetrics and Gynecology, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China.
² Department of Obstetrics and Gynecology, Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China. maggie1974@126.com.
³ Department of Obstetrics and Gynecology, Shanghai First Maternity and Infant Hospital Affiliated to Shanghai Tong Ji University, Shanghai, China. Wanxiaoping61@126.com.

PMID: 25448606
DOI: 10.14670/HH-30.539

Abstract

Endometrial cancer (EC) is the most common gynecologic malignancy. MicroRNAs (miRNAs) were recently associated with carcinogenesis and progression of EC. In this review, we discuss recent advances and the emerging role of miRNAs in EC and their clinical implications, with special emphasis on the differences between deregulated miRNAs in type I and type II EC, as well as the impact of this dysregulation on EC initiation and progression.

Publication types

Review

MeSH terms

Drug Resistance, Neoplasm
Endometrial Neoplasms / diagnosis
Endometrial Neoplasms / genetics*
Endometrial Neoplasms / metabolism
Estrogen Receptor alpha / metabolism
Female
Gene Expression Regulation, Neoplastic*
Humans
Membrane Glycoproteins / metabolism
MicroRNAs / metabolism*
Neoplasm Metastasis
PTEN Phosphohydrolase / metabolism
Phosphatidylinositol 3-Kinases / metabolism
Prognosis
Protein-Tyrosine Kinases / metabolism
Receptor, trkB
Signal Transduction

Substances

ESR1 protein, human
Estrogen Receptor alpha
Membrane Glycoproteins
MicroRNAs
Protein-Tyrosine Kinases
Receptor, trkB
tropomyosin-related kinase-B, human
PTEN Phosphohydrolase
PTEN protein, human