Penthorin A and B, two unusual 2,4'-epoxy-8,5'-neolignans from Penthorum chinese

Fitoterapia. 2015 Jan:100:7-10. doi: 10.1016/j.fitote.2014.11.006. Epub 2014 Nov 15.

Abstract

Two new 2,4'-epoxy-8,5'-neolignans (1 and 2), together with five known 7,9';7',9-diepoxylignans (3-7), were isolated from an ethyl acetate soluble portion of a hepatoprotective water decoction of Penthorum chinese. Their structures and absolute configurations were elucidated by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. This is the second report of 2,4'-epoxy-8,5'-neolignans from plants. Compounds 2, 6, and 7 showed in vitro protective activities against acetaminophen-induced hepatocyte injury at 5 μM.

Keywords: 2,4′-Epoxy-8,5′-neolignans; Absolute configuration; ECD calculation; Hepatoprotective activity; Penthorum chinese.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetaminophen / adverse effects
  • Cell Line
  • Hepatocytes / drug effects*
  • Humans
  • Lignans / chemistry*
  • Lignans / isolation & purification
  • Molecular Structure
  • Saxifragaceae / chemistry*

Substances

  • Lignans
  • penthorin A
  • penthorin B
  • Acetaminophen