NAIP inflammasomes give the NOD to bacterial ligands

Vivien I Maltez; Edward A Miao

doi:10.1016/j.it.2014.10.002

NAIP inflammasomes give the NOD to bacterial ligands

Trends Immunol. 2014 Nov;35(11):503-4. doi: 10.1016/j.it.2014.10.002. Epub 2014 Oct 18.

Authors

Vivien I Maltez¹, Edward A Miao²

Affiliations

¹ Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
² Department of Microbiology and Immunology, Center for Gastrointestinal Biology and Disease, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. Electronic address: emiao@med.unc.edu.

Abstract

NLRs are innate immune sensors that monitor the sanctity of the cytosolic compartment. In a recent paper in Molecular Cell, Tenthorey et al. reveal a novel ligand-sensing interface within regions of the oligomerization domain of the NAIPs, rather than within the leucine-rich repeats, as was anticipated.

Publication types

Comment

MeSH terms

Animals
Apoptosis Regulatory Proteins / metabolism*
Bacterial Proteins / metabolism*
Calcium-Binding Proteins / metabolism*
Humans
Inflammasomes / metabolism*
Neuronal Apoptosis-Inhibitory Protein / metabolism*

Substances

Apoptosis Regulatory Proteins
Bacterial Proteins
Calcium-Binding Proteins
Inflammasomes
Neuronal Apoptosis-Inhibitory Protein

Grants and funding

R01 AI097518/AI/NIAID NIH HHS/United States