A lignin glycoside and a nortriterpenoid from Kadsura coccinea

Chin J Nat Med. 2014 Oct;12(10):782-5. doi: 10.1016/S1875-5364(14)60119-9. Epub 2014 Oct 31.

Abstract

Aim: To study the chemical constituents of the roots and stem bark of Kadsura coccinea.

Method: Compounds were isolated by column chromatography on silica gel and Sephadex LH-20, and finally purified by prep-HPLC. Their structures were elucidated by extensive spectroscopic methods, including 1D- and 2D-NMR, and HR-ESI-MS.

Results: Two compounds were determined as (7'S,8'S,8R)-(8β,8'α)-dimethyl-4,4'-dihydroxy-5,3'-dimethoxy-5'-cyclolignan glucoside (1) and micrandiactone H (2), respectively.

Conclusion: Compunds 1 and 2 are new and neither showed inhibitory effects on nitric oxide (NO) production in lipopolysaccharide-induced RAW264.7 macrophages.

Keywords: Kadsura coccinea; Lignan glucoside; Schisandraceae; Triterpenoid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line
  • Glycosides / chemistry*
  • Glycosides / isolation & purification
  • Glycosides / pharmacology
  • Kadsura / chemistry*
  • Lignin / chemistry*
  • Lignin / isolation & purification
  • Lignin / pharmacology
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Plant Extracts / chemistry*
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry

Substances

  • Glycosides
  • Plant Extracts
  • Nitric Oxide
  • Lignin