Special considerations/technical limitations of blood-oxygen-level-dependent functional magnetic resonance imaging

Domenico Zacà; Shruti Agarwal; Sachin K Gujar; Haris I Sair; Jay J Pillai

doi:10.1016/j.nic.2014.07.006

Special considerations/technical limitations of blood-oxygen-level-dependent functional magnetic resonance imaging

Neuroimaging Clin N Am. 2014 Nov;24(4):705-15. doi: 10.1016/j.nic.2014.07.006. Epub 2014 Sep 2.

Authors

Domenico Zacà¹, Shruti Agarwal², Sachin K Gujar², Haris I Sair², Jay J Pillai³

Affiliations

¹ Center for Mind/Brain Sciences, University of Trento, Via delle Regole 101, Mattarello (TN) 38121, Italy; Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA.
² Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA.
³ Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins Hospital, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA. Electronic address: jpillai1@jhmi.edu.

PMID: 25441509
DOI: 10.1016/j.nic.2014.07.006

Abstract

In this review, limitations affecting the results of presurgical mapping with blood-oxygen-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) are discussed. There is a great need to standardize fMRI acquisition and analysis methods and establish guidelines to address quality control issues. Several national and international organizations are formulating guidelines and standards for both clinical and research applications of BOLD fMRI. Consensus regarding management of these issues will likely both improve the clinical standard of care and enhance future research applications of fMRI.

Keywords: Blood-oxygen-level-dependent; Functional magnetic resonance imaging; Special considerations; Technical limitations.

Publication types

Review

MeSH terms

Brain / physiology*
Brain Mapping / standards*
Humans
Image Enhancement / standards
Image Interpretation, Computer-Assisted / standards*
Internationality
Magnetic Resonance Imaging / standards*
Nerve Net / physiopathology*
Oxygen / blood*
Practice Guidelines as Topic

Substances

Oxygen