Differences between murine and human sepsis

Peter Chen; Mile Stanojcic; Marc G Jeschke

doi:10.1016/j.suc.2014.08.001

Differences between murine and human sepsis

Surg Clin North Am. 2014 Dec;94(6):1135-49. doi: 10.1016/j.suc.2014.08.001. Epub 2014 Sep 27.

Authors

Peter Chen¹, Mile Stanojcic¹, Marc G Jeschke²

Affiliations

¹ Sunnybrook Research Institute, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.
² Department of Immunology, University of Toronto, Toronto, Ontario, Canada; Division of Plastic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Ross Tilley Burn Centre, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada. Electronic address: marc.jeschke@sunnybrook.ca.

Abstract

Sepsis can be defined as a systemic inflammatory response syndrome occurring in the presence of an infectious source. Over the past 25 years, numerous guidelines have been established to clarify definitions and improve the overall management of clinical sepsis. In light of these multiple paradigm shifts, this review attempts to summarize the innate immunologic alterations that manifest during sepsis, establish and compare mouse models of sepsis with the clinical course, and discuss the authors' views on additional elements that should be considered in modeling and predicting clinical sepsis from the standpoint of a basic research setting.

Keywords: Anti-inflammatory; Cytokines; Leukocytes; Proinflammatory; Sepsis; Systemic inflammatory response syndrome.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Disease Models, Animal*
Humans
Mice*
Sepsis* / diagnosis
Sepsis* / immunology
Sepsis* / microbiology
Sepsis* / physiopathology

Abstract

Publication types

MeSH terms

Grants and funding