[Mammary analog secretory carcinoma of the parotid gland]

Ann Pathol. 2014 Oct;34(5):384-7. doi: 10.1016/j.annpat.2014.08.004. Epub 2014 Sep 26.
[Article in French]

Abstract

Mammary analog secretory carcinoma (MASC) of the parotid gland is a rare and recently described lesion. We report the case of a 46-year-old man with a tumor of the parotid gland which was carried to the diagnosis of MASC. Diagnostic was confirmed by highlighting the ETV6-NTRK3 gene translocation. However, some morphologic and immunohistochemical features are suggestive of this entity. This carcinoma should be distinguished from its main differential diagnoses: acinic cell carcinoma and low grade cribriform cystadenocarcinoma.

Keywords: Analogue des carcinomes sécrétoires mammaires; Carcinome salivaire sécrétoire; ETV6; Glande parotide; Mammary analog secretory carcinoma; Parotid gland.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Biomarkers, Tumor / analysis
  • Carcinoma / chemistry
  • Carcinoma / genetics
  • Carcinoma / pathology*
  • Carcinoma, Acinar Cell
  • Cystadenocarcinoma
  • Diagnosis, Differential
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Oncogene Proteins, Fusion / genetics
  • Parotid Neoplasms / chemistry
  • Parotid Neoplasms / genetics
  • Parotid Neoplasms / pathology*
  • Translocation, Genetic

Substances

  • Biomarkers, Tumor
  • ETV6-NTRK3 fusion protein, human
  • Oncogene Proteins, Fusion