Hepatitis B virus infection and the risk of male infertility: a population-based analysis

Fu-Hsiung Su; Shih-Ni Chang; Fung-Chang Sung; Chien-Tien Su; Ying-Hua Shieh; Cheng-Chieh Lin; Chih-Ching Yeh

doi:10.1016/j.fertnstert.2014.09.017

Hepatitis B virus infection and the risk of male infertility: a population-based analysis

Fertil Steril. 2014 Dec;102(6):1677-84. doi: 10.1016/j.fertnstert.2014.09.017. Epub 2014 Oct 22.

Authors

Fu-Hsiung Su¹, Shih-Ni Chang², Fung-Chang Sung³, Chien-Tien Su⁴, Ying-Hua Shieh⁵, Cheng-Chieh Lin⁶, Chih-Ching Yeh⁷

Affiliations

¹ Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Department of Family Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan.
² PhD Program for Cancer Biology and Drug Discovery, China Medical University, Taichung, Taiwan; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; Management Office for Health Data, China Medical University, Taichung, Taiwan.
³ Management Office for Health Data, China Medical University, Taichung, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan.
⁴ Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan; School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.
⁵ Department of Family Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.
⁶ Division of Family Medicine, China Medical University, Taichung, Taiwan.
⁷ Department of Public Health, China Medical University, Taichung, Taiwan; School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan. Electronic address: ccyeh@tmu.edu.tw.

PMID: 25439807
DOI: 10.1016/j.fertnstert.2014.09.017

Abstract

Objective: To evaluate the risk of male infertility among patients with hepatitis B virus (HBV) infection.

Design: A nationwide, population-based cohort study.

Setting: Not applicable.

Patient(s): Men infected with HBV (n = 5,138) and men without HBV infection (n = 25,690).

Intervention(s): None.

Main outcome measure(s): Male infertility, as defined by the International Classification of Diseases, Ninth Revision, Clinical Modification.

Result(s): The incidence of infertility was 1.59 times higher in patients with HBV infection than in those without HBV infection (2.21 vs. 1.39 per 1,000 person-years). The risk of developing infertility remained significant among patients with HBV infection (hazard ratio 1.52, 95% confidence interval 1.20-1.92) after adjusting for covariates in a multivariate Cox proportional hazards model.

Conclusion(s): The data show an increased incidence and risk of infertility among men with HBV infection compared with men without HBV.

Keywords: Hepatitis B virus; male infertility; population-based study.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cohort Studies
Hepatitis B / epidemiology*
Hepatitis B Surface Antigens / immunology
Humans
Incidence
Infertility, Male / epidemiology*
Infertility, Male / immunology
Male
Middle Aged
Population Surveillance
Risk

Substances

Hepatitis B Surface Antigens