Ultrasound diagnosis of carotid artery stiffness in patients with ischemic leukoaraiosis

Abstract

The pathophysiology of ischemic leukoaraiosis (ILA) is unknown. It was recently found that ILA patients have increased aortic stiffness. Carotid stiffness is a more specific parameter and could have value as a non-invasive diagnostic value for ILA. Therefore, using color-coded duplex sonography, we compared local carotid stiffness parameters of 59 patients with ILA with those of 45 well-matched controls. The diagnosis of ILA was based on exclusion of other causes of white matter changes seen on magnetic resonance imaging. Pulse wave velocity β (PWVβ, m/s), pressure-strain elasticity modulus (Ep, kPa), β index and augmentation index (Aix, %) values were higher and arterial compliance (AC, mm(2)/kPa) values were lower in the ILA group; however, only Ep and PWVβ reached statistical significance (p ≤ 0.05). β, Ep and PWVβ exhibited an increasing trend with higher Fazekas score, though only Ep reached significance (p = 0.05). The main conclusion was that Ep and PWVβ could have a diagnostic role in patients with ILA.

Keywords: Carotid arterial stiffness; Doppler sonography; Echo tracking system; Leukoaraiosis; Vascular risk factors; White matter changes.