HIV: a vicTIM

Jiri Vlach; Jamil S Saad

doi:10.1016/j.tim.2014.09.008

HIV: a vicTIM

Trends Microbiol. 2014 Nov;22(11):603-4. doi: 10.1016/j.tim.2014.09.008. Epub 2014 Oct 16.

Authors

Jiri Vlach¹, Jamil S Saad²

Affiliations

¹ Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294.
² Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294. Electronic address: saad@uab.edu.

PMID: 25438615
DOI: 10.1016/j.tim.2014.09.008

Abstract

TIM proteins are known to promote viral entry into host cells. Unexpectedly, a recent study has shown that TIM proteins also inhibit HIV-1 release from the host cell by directly binding to phosphatidylserine exposed on the virus surface, providing details on a new role of TIM proteins in HIV replication.

Keywords: HIV; TIM; phosphatidylserine (PS).

MeSH terms

HIV-1 / physiology*
Hepatitis A Virus Cellular Receptor 1
Hepatitis A Virus Cellular Receptor 2
Host-Pathogen Interactions*
Humans
Membrane Glycoproteins / metabolism*
Membrane Proteins / metabolism
Models, Biological
Receptors, Virus / metabolism*
Virus Release*

Substances

HAVCR1 protein, human
HAVCR2 protein, human
Hepatitis A Virus Cellular Receptor 1
Hepatitis A Virus Cellular Receptor 2
Membrane Glycoproteins
Membrane Proteins
Receptors, Virus
TIMD4 protein, human