Abstract
The synthesis of resolved P-metalated nucleoside phosphoramidites is described. These rare compounds were initially prepared with gold as the metal center; however, the gold can be removed using basic phosphines or solid-supported triphenylphosphine. Treatment of the free nucleoside phosphoramidite with a platinum source generated a unique platinated dinucleoside species with a diastereomeric ratio of >99:1.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Dimerization
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Nucleosides / chemical synthesis
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Nucleosides / chemistry*
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Organophosphorus Compounds / chemical synthesis
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Organophosphorus Compounds / chemistry*
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Organoplatinum Compounds / chemical synthesis
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Organoplatinum Compounds / chemistry*
Substances
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Nucleosides
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Organophosphorus Compounds
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Organoplatinum Compounds
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phosphoramidite