A potent antimicrobial compound isolated from Clathria cervicornis

Bioorg Med Chem Lett. 2015 Jan 1;25(1):67-9. doi: 10.1016/j.bmcl.2014.11.012. Epub 2014 Nov 6.

Abstract

The sponge of Clathria cervicornis is commonly used in traditional medicine. This study aims to identify the active compound in C. cervicornis and to evaluate its antimicrobial activity. The purified active compound was determined to be crambescidin 800 and was found to be highly active against Acinetobacter baumannii (minimal inhibitory concentration, MIC=2 μg/ml), Klebsiella pneumoniae (MIC=1 μg/ml) and Pseudomonas aeruginosa (MIC=1 μg/ml). A potent antimicrobial compound, crambescidin 800, was isolated in Clathria cervicornis. It is extremely active against three common pathogenic bacteria.

Keywords: Antimicrobial activity; Clathria cervicornis; Crambescidin 800; Minimal inhibitory concentration; Natural antimicrobial.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / isolation & purification
  • Anti-Infective Agents / pharmacology
  • Biological Products / chemistry*
  • Biological Products / isolation & purification*
  • Biological Products / pharmacology
  • Klebsiella pneumoniae / drug effects
  • Klebsiella pneumoniae / physiology
  • Microbial Sensitivity Tests / methods
  • Porifera*

Substances

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Biological Products