Three new polyunsaturated lipids from a Guangxi marine sponge Haliclona sp

J Asian Nat Prod Res. 2015;17(2):114-9. doi: 10.1080/10286020.2014.985769. Epub 2014 Dec 1.

Abstract

Three new polyunsaturated lipids, (6Z,9Z,12Z,15Z)-octadeca-6,9,12,15-tetraen-3-one (1), (6Z,9Z,12Z,15Z)-1-bromooctadeca-6,9,12,15-tetraen-3-one (2), and (Z)-ethyl docos-5-enoate (3), together with two known polyunsaturated lipids, 4(Z),7(Z),10(Z)-tridecatrienoic acid (4) and (6Z,9Z,12Z,15Z)-octadeca-1,6,9,12,15-pentaen-3-one (5), were isolated from the marine sponge Haliclona sp., which was collected from Guangxi, using HSCCC and HPLC methods. Chemical structures of the five compounds were elucidated by spectroscopic techniques.

Keywords: Haliclona sp; marine sponge; polyunsaturated lipids; structural elucidation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • China
  • Chromatography, High Pressure Liquid
  • Fatty Acids, Unsaturated / chemistry
  • Fatty Acids, Unsaturated / isolation & purification*
  • Fatty Acids, Unsaturated / pharmacology
  • Haliclona / chemistry*
  • Macrophages
  • Marine Biology
  • Mice
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Stereoisomerism

Substances

  • (6Z,9Z,12Z,15Z)-1-bromooctadeca-6,9,12,15-tetraen-3-one
  • (6Z,9Z,12Z,15Z)-octadeca-6,9,12,15-tetraen-3-one
  • (Z)-ethyl docos-5-enoate
  • Anti-Inflammatory Agents, Non-Steroidal
  • Fatty Acids, Unsaturated