Abstract
Theiler's murine encephalomyelitis virus (TMEV) can induce demyelination or myocarditis in susceptible mouse strains. A deficiency of NKT cells exacerbated TMEV-induced demyelinating disease (TMEV-IDD) in SJL/J and BALB/c mice. In C57BL/6 background, however, NKT-cell-deficient Jα18 KO mice remained as resistant to TMEV-IDD as wild-type mice. Echocardiography and histology showed that Jα18 KO mice developed more severe myocarditis (greater T cell infiltration and fibrosis) than wild-type mice, suggesting a protective role of NKT cells in myocarditis in C57BL/6 mice. Jα18 KO mice had higher cardiac viral RNA and anti-viral antibody titers, but had lower lymphoproliferation and IL-4 and IL-10 production.
Keywords:
CNS demyelinating disease; GDVII strain; Multiple sclerosis; Picornaviridae infection; Seizure; Tropism.
Copyright © 2014 Elsevier B.V. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Age Factors
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Animals
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Antibodies / blood
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Antibodies / pharmacology
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Cardiovirus Infections / complications*
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Cardiovirus Infections / pathology
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Cell Proliferation / drug effects
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Cell Proliferation / physiology
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Central Nervous System / pathology
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Central Nervous System / virology
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Cytokines / metabolism
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Demyelinating Diseases / etiology*
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Demyelinating Diseases / virology
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Fibrosis / pathology
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Lymphocytes / drug effects
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Lymphocytes / physiology
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Mice
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Mice, Inbred BALB C
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Mice, Inbred C57BL
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Mice, Knockout
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Myocarditis / etiology*
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Myocarditis / pathology
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Myocarditis / virology
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Natural Killer T-Cells / physiology*
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Receptors, Antigen, T-Cell, alpha-beta / deficiency
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Receptors, Antigen, T-Cell, alpha-beta / genetics
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Receptors, Antigen, T-Cell, alpha-beta / immunology
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Species Specificity
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Theilovirus / genetics
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Theilovirus / immunology
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Theilovirus / pathogenicity
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Time Factors
Substances
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Antibodies
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Cytokines
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Receptors, Antigen, T-Cell, alpha-beta