Abstract
Energy metabolism and immunity are characterized as abnormal in schizophrenia. Because these two systems are highly coordinated, we measured expression of prototypic obesogenic and immunogenic genes in freshly harvested PBMC from controls and participants with schizophrenia. We report significant increases in PPARγ, SREBP1, IL-6 and TNFα, and decreases in PPARα and C/EPBα and mRNA levels from patients with schizophrenia, with additional BMI interactions, characterizing dysregulation of genes relating to metabolic-inflammation in schizophrenia.
Keywords:
Inflammation; Obesity; Schizophrenia.
Published by Elsevier Ireland Ltd.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adult
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Antipsychotic Agents / adverse effects
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Antipsychotic Agents / therapeutic use
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CCAAT-Enhancer-Binding Proteins / genetics*
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Energy Metabolism / genetics*
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Female
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Gene Expression / genetics
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Humans
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Inflammation / genetics
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Interleukin-6 / genetics
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Leukocytes, Mononuclear / metabolism
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Male
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Middle Aged
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Obesity / genetics
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Overweight / chemically induced
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Overweight / diagnosis
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Overweight / genetics*
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PPAR alpha / genetics*
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PPAR gamma / genetics*
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RNA, Messenger / genetics
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Schizophrenia / diagnosis
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Schizophrenia / drug therapy
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Schizophrenia / genetics*
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Sterol Regulatory Element Binding Protein 1 / genetics*
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Tumor Necrosis Factor-alpha / genetics
Substances
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Antipsychotic Agents
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CCAAT-Enhancer-Binding Proteins
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CEBPA protein, human
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Interleukin-6
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PPAR alpha
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PPAR gamma
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RNA, Messenger
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SREBF1 protein, human
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Sterol Regulatory Element Binding Protein 1
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Tumor Necrosis Factor-alpha