Hemopoietic cell proliferation and death in the regenerating fetal rat liver

Bull Exp Biol Med. 2014 Dec;158(2):284-6. doi: 10.1007/s10517-014-2741-4. Epub 2014 Nov 29.

Abstract

The proliferation and death of hemopoietic cells in the regenerating liver of 17-day outbred albino rat fetuses were studied during 2 days after resection of 20% of the organ. The mitotic index of hemopoietic cells in the resected liver increased significantly 24 h after the operation in comparison with the control fetuses. No increase in the counts of apoptotic hemopoietic cells was detected in the regenerating liver. Hence, resection of 20% of the liver in rat fetuses stimulated the proliferation of hemopoietic cells and did not stimulate their apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / physiology
  • Cell Proliferation / physiology*
  • Fetus / physiology*
  • Hematopoietic Stem Cells / physiology*
  • Immunohistochemistry
  • Liver Regeneration / physiology*
  • Mitotic Index
  • Rats