Abstract
The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adaptor Proteins, Signal Transducing / chemistry*
-
Cell Cycle Proteins
-
Humans
-
Intrinsically Disordered Proteins / chemistry*
-
Magnetic Resonance Spectroscopy
-
Models, Molecular
-
Phosphoproteins / chemistry*
-
Protein Structure, Secondary
Substances
-
Adaptor Proteins, Signal Transducing
-
Cell Cycle Proteins
-
EIF4EBP1 protein, human
-
Intrinsically Disordered Proteins
-
Phosphoproteins