Actinobacteria mediated synthesis of nanoparticles and their biological properties: A review

Crit Rev Microbiol. 2016;42(2):209-21. doi: 10.3109/1040841X.2014.917069. Epub 2014 Nov 28.

Abstract

Nanotechnology is gaining tremendous attention in the present century due to its expected impact on many important areas such as medicine, energy, electronics, and space industries. In this context, actinobacterial biosynthesis of nanoparticles is a reliable, eco-friendly, and important aspect of green chemistry approach that interconnects microbial biotechnology and nanobiotechnology. Antibiotics produced by actinobacteria are popular in almost all the therapeutic measures and it is known that these microbes are also helpful in the biosynthesis of nanoparticles with good surface and size characteristics. In fact, actinobacteria are efficient producers of nanoparticles that show a range of biological properties, namely, antibacterial, antifungal, anticancer, anti-biofouling, anti-malarial, anti-parasitic, antioxidant, etc. This review describes the potential use of the actinobacteria as the novel sources for the biosynthesis of nanoparticles with improved biomedical applications.

Keywords: Actinobacteria; biomedical applications; nanoparticles; nanotechnology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actinobacteria / physiology*
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / metabolism
  • Anti-Infective Agents / pharmacology
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / metabolism
  • Antineoplastic Agents / pharmacology
  • Antioxidants / chemistry
  • Antioxidants / metabolism
  • Antioxidants / pharmacology
  • Biotechnology*
  • Extracellular Space / metabolism
  • Humans
  • Intracellular Space / metabolism
  • Nanoparticles / chemistry
  • Nanoparticles / classification
  • Nanoparticles / metabolism*
  • Nanoparticles / ultrastructure
  • Nanotechnology*

Substances

  • Anti-Infective Agents
  • Antineoplastic Agents
  • Antioxidants