Polylactide conjugates of camptothecin with different drug release abilities

Molecules. 2014 Nov 25;19(12):19460-70. doi: 10.3390/molecules191219460.

Abstract

Camptothecin-polylactide conjugates (CMPT-PLA) were synthesized by covalent incorporation of CMPT into PLA of different microstructure, i.e., atactic PLA and atactic-block-isotactically enriched PLA (Pm = 0.79) via urethane bonds. The kinetic release of CPMT from CMPT-PLA conjugates, tested in vitro under different conditions, is possible in both cases and notably, strongly dependent on PLA microstructure. It shows that release properties of drug-PLA conjugates can be tailored by controlled design of the PLA microstructure, and allow in the case of CMPT-PLA conjugates for the development of highly controlled biodegradable CMPT systems-important delivery systems for anti-cancer agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aliivibrio fischeri / drug effects
  • Camptothecin / chemical synthesis
  • Camptothecin / chemistry
  • Camptothecin / pharmacology*
  • Camptothecin / toxicity
  • Drug Liberation*
  • Hydrogen-Ion Concentration
  • Polyesters / chemical synthesis
  • Polyesters / chemistry*
  • Polyesters / toxicity
  • Proton Magnetic Resonance Spectroscopy
  • Toxicity Tests

Substances

  • Polyesters
  • poly(lactide)
  • Camptothecin