A Nile blue based infrared fluorescent probe: imaging tumors that over-express cyclooxygenase-2

Chem Commun (Camb). 2015 Jan 14;51(4):792-5. doi: 10.1039/c4cc08915d.

Abstract

The first Golgi-localized cyclooxygenase-2 (COX-2)-specific near-infrared (NIR) fluorescent probe, Niblue-C6-IMC, able to detect cancer cells, was designed. Importantly, Niblue-C6-IMC preferentially labeled the tumors in a mouse tumor model with deep tissue penetration capacity. It may be a promising molecular tool for guiding tumor resection during surgery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cyclooxygenase 2 / analysis*
  • Fluorescent Dyes* / chemistry
  • Hep G2 Cells
  • Humans
  • Infrared Rays
  • Mice
  • Mice, Nude
  • Models, Molecular
  • Molecular Imaging*
  • Neoplasms / diagnosis
  • Neoplasms / enzymology*
  • Optical Imaging*
  • Oxazines* / chemistry

Substances

  • Fluorescent Dyes
  • Oxazines
  • Nile Blue
  • Cyclooxygenase 2