Abstract
The first Golgi-localized cyclooxygenase-2 (COX-2)-specific near-infrared (NIR) fluorescent probe, Niblue-C6-IMC, able to detect cancer cells, was designed. Importantly, Niblue-C6-IMC preferentially labeled the tumors in a mouse tumor model with deep tissue penetration capacity. It may be a promising molecular tool for guiding tumor resection during surgery.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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Cyclooxygenase 2 / analysis*
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Fluorescent Dyes* / chemistry
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Hep G2 Cells
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Humans
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Infrared Rays
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Mice
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Mice, Nude
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Models, Molecular
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Molecular Imaging*
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Neoplasms / diagnosis
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Neoplasms / enzymology*
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Optical Imaging*
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Oxazines* / chemistry
Substances
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Fluorescent Dyes
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Oxazines
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Nile Blue
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Cyclooxygenase 2