A New Bioactive Polylactide-based Composite with High Mechanical Strength

Quanxiao Dong; Laurence C Chow; Tongxin Wang; Stanislav A Frukhtbeyn; Feng Wang; Mingshu Yang; James W Mitchell

doi:10.1016/j.colsurfa.2014.05.047

A New Bioactive Polylactide-based Composite with High Mechanical Strength

Colloids Surf A Physicochem Eng Asp. 2014 Sep 5:457:256-262. doi: 10.1016/j.colsurfa.2014.05.047.

Authors

Quanxiao Dong¹, Laurence C Chow², Tongxin Wang³, Stanislav A Frukhtbeyn², Feng Wang⁴, Mingshu Yang⁴, James W Mitchell⁵

Affiliations

¹ Crest Center for Nanomaterials, College of Engineering, Howard University, Washington, DC 20059, USA ; College of Dentistry, Howard University, Washington, DC 20059, USA ; CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese, Academy of Sciences, Beijing 100190, China ; Beijing Engineering Research Center of Architectural Functional Macromolecular Materials, Beijing Building Construction Research Institute, Co., Ltd., Beijing, 100039, China.
² American Dental Association Foundation, Dr. Anthony Volpe Research Center, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.
³ Crest Center for Nanomaterials, College of Engineering, Howard University, Washington, DC 20059, USA ; College of Dentistry, Howard University, Washington, DC 20059, USA.
⁴ CAS Key Laboratory of Engineering Plastics, Institute of Chemistry, Chinese, Academy of Sciences, Beijing 100190, China.
⁵ Crest Center for Nanomaterials, College of Engineering, Howard University, Washington, DC 20059, USA.

Abstract

A new bioresorbable polylactide/calcium phosphate composite with improved mechanical strengths and a more basic filler, tetracalcium phosphate (TTCP), was prepared by melt compounding. N-(2-aminoethyl)-3-aminoproplytrimethoxysilane (AEAPS) and pyromellitic dianhydride (PMDA) were used to improve the interfacial adhesion between TTCP and polylactide (PLA). While AEAPS improved the dispersion of TTCP in the matrix, PMDA might react with the terminal hydroxyl group of PLA and the amino group on the surface of AEAPS modified TTCP, which could further enhance the interfacial strength. The tensile strength was improved to 68.4 MPa for the PLA/TTCP-AEAPS composite from 51.5 MPa for the PLA/TTCP composite (20 wt% of TTCP). Dynamic mechanical analysis suggested that there was a 51 % improvement in storage modulus compared to that of PLA alone, when PMDA (0.2 wt% of PMDA) was incorporated into the PLA/TTCP-AEAPS composite (5 wt% of TTCP). Using this new bioresorbable PLA composite incorporated with a more basic filler for biomedical application, the inflammation and allergic effect resulted from the degraded acidic product are expected to be reduced.

Keywords: composite; mechanical properties; polylactide; tetracalcium phosphate.

Grants and funding

R01 DE021786/DE/NIDCR NIH HHS/United States