Abstract
A gold nanoparticle was radiolabeled with (125)I and (111)In and functionalized with an MMP9-cleavable peptide to form a multispectral SPECT imaging contrast agent. Peptide cleavage from the nanoprobe by MMP9 was observed in vitro, and distinct pharmacokinetic properties of the contrast agent were observed between tumors with high or low MMP9 expression.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Animals
-
Cell Line, Tumor
-
Contrast Media / chemistry*
-
Contrast Media / pharmacokinetics
-
Gold / chemistry
-
Humans
-
Indium Radioisotopes / chemistry
-
Iodine Radioisotopes / chemistry
-
Matrix Metalloproteinase 9 / metabolism
-
Metal Nanoparticles / chemistry*
-
Mice
-
Tissue Distribution
-
Tomography, Emission-Computed, Single-Photon*
-
Transplantation, Heterologous
Substances
-
Contrast Media
-
Indium Radioisotopes
-
Iodine Radioisotopes
-
Gold
-
Matrix Metalloproteinase 9