Label-free detection of Alzheimer's disease through the ADP3 peptoid recognizing the serum amyloid-beta42 peptide

Zijian Zhao; Ling Zhu; Xiangli Bu; Huailei Ma; Shu Yang; Yanlian Yang; Zhiyuan Hu

doi:10.1039/c4cc07037b

Label-free detection of Alzheimer's disease through the ADP3 peptoid recognizing the serum amyloid-beta42 peptide

Chem Commun (Camb). 2015 Jan 14;51(4):718-21. doi: 10.1039/c4cc07037b.

Authors

Zijian Zhao¹, Ling Zhu, Xiangli Bu, Huailei Ma, Shu Yang, Yanlian Yang, Zhiyuan Hu

Affiliation

¹ National Center for Nanoscience and Technology, No. 11, Beiyitiao Zhongguancun, Beijing, 100190, P.R. China. zhul@nanoctr.cn huzy@nanoctr.cn.

PMID: 25418132
DOI: 10.1039/c4cc07037b

Abstract

The early diagnosis of Alzheimer's disease (AD) is challenging due to the lack of reliable methods for detecting its biomarkers in the noninvasive biopsies. We used surface plasmon resonance imaging to identify AD based on the detection of amyloid-beta42 in the serum by the ADP3 peptoid.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alzheimer Disease / blood*
Alzheimer Disease / diagnosis
Amyloid beta-Peptides / blood*
Equipment Design
Humans
Peptide Fragments / blood*
Peptoids / chemistry*
Surface Plasmon Resonance / instrumentation*

Substances

Amyloid beta-Peptides
Peptide Fragments
Peptoids
amyloid beta-protein (1-42)