Primaquine treatment suppresses experimental autoimmune encephalomyelitis severity

CNS Neurosci Ther. 2014 Dec;20(12):1061-4. doi: 10.1111/cns.12357.

Authors

Fábio Zanucoli¹, Rodolfo Thomé, Amanda Pires Bonfanti, Ana Carolina de Carvalho, Luidy K Issayama, Thiago Alves da Costa, Rosária Di Gangi, Isadora Tassinari Ferreira, André Luis Bombeiro, Alexandre Leite Rodrigues de Oliveira, Liana Verinaud

Affiliation

¹ Department of Structural and Functional Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Analysis of Variance
Animals
Anti-Inflammatory Agents / therapeutic use*
Calcium-Binding Proteins / metabolism
Central Nervous System / drug effects
Central Nervous System / metabolism
Central Nervous System / pathology
Cytokines / metabolism
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental / chemically induced
Encephalomyelitis, Autoimmune, Experimental / drug therapy*
Encephalomyelitis, Autoimmune, Experimental / immunology
Encephalomyelitis, Autoimmune, Experimental / pathology
Forkhead Transcription Factors / metabolism
Freund's Adjuvant / toxicity
Glial Fibrillary Acidic Protein / metabolism
Mice
Mice, Inbred C57BL
Microfilament Proteins / metabolism
Myelin-Oligodendrocyte Glycoprotein / toxicity
Nerve Tissue Proteins / metabolism
Peptide Fragments / toxicity
Primaquine / therapeutic use*
Severity of Illness Index
T-Lymphocytes, Regulatory / drug effects
T-Lymphocytes, Regulatory / metabolism

Substances

Aif1 protein, mouse
Anti-Inflammatory Agents
Calcium-Binding Proteins
Cytokines
Forkhead Transcription Factors
Foxp3 protein, mouse
Glial Fibrillary Acidic Protein
Microfilament Proteins
Myelin-Oligodendrocyte Glycoprotein
Nerve Tissue Proteins
Peptide Fragments
myelin oligodendrocyte glycoprotein (35-55)
Freund's Adjuvant
Primaquine