Time in motion: the molecular clock meets the microbiome

Xue Liang; Frederic D Bushman; Garret A FitzGerald

doi:10.1016/j.cell.2014.10.020

Time in motion: the molecular clock meets the microbiome

Cell. 2014 Oct 23;159(3):469-70. doi: 10.1016/j.cell.2014.10.020.

Authors

Xue Liang¹, Frederic D Bushman², Garret A FitzGerald³

Affiliations

¹ Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.
² Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA.
³ Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, PA 19104, USA. Electronic address: garret@upenn.edu.

PMID: 25417097
DOI: 10.1016/j.cell.2014.10.020

Abstract

Thaiss et al. report that the intestinal microbiota undergoes diurnal oscillation, which is controlled by host feeding time. Disruption of the host circadian clock induces dysbiosis, which is associated with host metabolic disorders.

Publication types

Comment

MeSH terms

Animals
Circadian Clocks*
Circadian Rhythm*
Glucose Intolerance*
Humans
Microbiota*

Grants and funding

U54 HL117798/HL/NHLBI NIH HHS/United States