Mitochondrial fusion through membrane automata

Adv Exp Med Biol. 2015:820:163-72. doi: 10.1007/978-3-319-09012-2_10.

Abstract

Studies have shown that malfunctions in mitochondrial processes can be blamed for diseases. However, the mechanism behind these operations is yet not sufficiently clear. In this work we present a novel approach to describe a biomolecular model for mitochondrial fusion using notions from the membrane computing. We use a case study defined in BioAmbient calculus and we show how to translate it in terms of a P automata variant. We combine brane calculi with (mem)brane automata to produce a new scheme capable of describing simple, realistic models. We propose the further use of similar methods and the test of other biomolecular models with the same behaviour.

MeSH terms

  • Animals
  • Computational Biology / methods*
  • Humans
  • Membrane Fusion / physiology*
  • Mitochondrial Dynamics / physiology*
  • Mitochondrial Membranes / physiology*
  • Mitochondrial Proteins / physiology
  • Models, Biological*

Substances

  • Mitochondrial Proteins