Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines

Molecules. 2014 Nov 18;19(11):18993-9006. doi: 10.3390/molecules191118993.

Abstract

Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 µM of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Membrane Permeability / drug effects
  • Furans / pharmacology
  • HT29 Cells
  • Humans
  • Inhibitory Concentration 50
  • MCF-7 Cells
  • Mitochondrial Membranes / drug effects
  • Neoplasms / drug therapy*
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes / pharmacology*
  • Terpenes / pharmacology
  • Tetrahydronaphthalenes / pharmacology

Substances

  • Furans
  • Polycyclic Sesquiterpenes
  • Sesquiterpenes
  • Terpenes
  • Tetrahydronaphthalenes
  • confertifolin
  • drimane
  • drimenol
  • polygodial