Abstract
Canine parvovirus type 2 (CPV-2) emerged in 1978 and spread worldwide within 2 years. Subsequently, CPV-2 was completely replaced by the variant CPV-2a, which is characterized by four specific capsid (VP2) mutations. The X-ray crystal structure of the CPV-2a capsid shows that each mutation confers small local changes. The loss of a hydrogen bond and introduction of a glycine residue likely introduce flexibility to sites that control interactions with the host receptor, antibodies, and sialic acids.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Capsid Proteins / chemistry
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Crystallography, X-Ray
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Dog Diseases / epidemiology
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Dog Diseases / virology*
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Dogs
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Host Specificity*
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Models, Molecular
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Mutant Proteins / chemistry
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Pandemics
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Parvoviridae Infections / epidemiology
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Parvoviridae Infections / veterinary*
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Parvoviridae Infections / virology
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Parvovirus, Canine / chemistry
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Parvovirus, Canine / isolation & purification
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Parvovirus, Canine / physiology*
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Protein Conformation
Substances
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Capsid Proteins
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Mutant Proteins