Abstract
PI4KIIIβ recruitment to Golgi membranes relies on GBF1/Arf and ACBD3. Enteroviruses such as poliovirus and coxsackievirus recruit PI4KIIIβ to their replication sites via their 3A proteins. Here, we show that human rhinovirus (HRV) 3A also recruited PI4KIIIβ to replication sites. Unlike other enterovirus 3A proteins, HRV 3A failed to bind GBF1. Although HRV 3A was previously shown to interact with ACBD3, our data suggest that PI4KIIIβ recruitment occurred independently of both GBF1 and ACBD3.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism*
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Guanine Nucleotide Exchange Factors / metabolism*
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Host-Pathogen Interactions*
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Humans
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Membrane Proteins / metabolism*
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Phosphotransferases (Alcohol Group Acceptor) / metabolism*
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Protein Binding
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Rhinovirus / physiology*
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Viral Core Proteins / metabolism*
Substances
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ACBD3 protein, human
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Adaptor Proteins, Signal Transducing
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GBF1 protein, human
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Guanine Nucleotide Exchange Factors
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Membrane Proteins
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Viral Core Proteins
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Phosphotransferases (Alcohol Group Acceptor)
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phosphatidylinositol 4-kinase IIIbeta, human