Refractive index dependent real-time plasmonic nanoprobes on a single silver nanocube for ultrasensitive detection of the lung cancer-associated miRNAs

Chem Commun (Camb). 2015;51(2):294-7. doi: 10.1039/c4cc06663d. Epub 2014 Nov 12.

Abstract

We developed a novel method for the real-time monitoring of the delicate change in refractive index (RI) when DNA or RNA hybridize near a DNA-capped silver nanocube (AgNC) surface. This method offers an alternative platform in the quantitative analysis of the trace lung cancer-associated miRNAs in label-free detection.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Biosensing Techniques / methods*
  • DNA, Single-Stranded / chemistry
  • Humans
  • Lung Neoplasms / diagnosis*
  • Metal Nanoparticles / chemistry*
  • MicroRNAs / analysis*
  • Refractometry / methods*
  • Sensitivity and Specificity
  • Silver / chemistry*

Substances

  • DNA, Single-Stranded
  • MIRN21 microRNA, human
  • MicroRNAs
  • Silver