Abstract
We developed a novel method for the real-time monitoring of the delicate change in refractive index (RI) when DNA or RNA hybridize near a DNA-capped silver nanocube (AgNC) surface. This method offers an alternative platform in the quantitative analysis of the trace lung cancer-associated miRNAs in label-free detection.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Biosensing Techniques / methods*
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DNA, Single-Stranded / chemistry
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Humans
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Lung Neoplasms / diagnosis*
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Metal Nanoparticles / chemistry*
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MicroRNAs / analysis*
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Refractometry / methods*
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Sensitivity and Specificity
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Silver / chemistry*
Substances
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DNA, Single-Stranded
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MIRN21 microRNA, human
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MicroRNAs
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Silver