The PI3K/AKT/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies

Br J Haematol. 2015 May;169(3):455-8. doi: 10.1111/bjh.13228. Epub 2014 Nov 19.

Authors

Amir Hossein Daneshmanesh¹, Mohammad Hojjat-Farsangi, Ali Moshfegh, Abdul Salam Khan, Eva Mikaelsson, Anders Österborg, Håkan Mellstedt

Affiliation

¹ Department of Oncology-Pathology, Immune and Gene Therapy Lab, CCK, Karolinska Institute and Karolinska University Hospital Solna, Stockholm, Sweden.

PMID: 25407287
DOI: 10.1111/bjh.13228

No abstract available

Keywords: PI3K/AKT/mTOR pathway; ROR1; apoptosis; chronic lymphocytic leukaemia; monoclonal antibodies.

Publication types

Letter

MeSH terms

Antibodies, Monoclonal / pharmacology*
Apoptosis / drug effects*
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
Phosphatidylinositol 3-Kinases / metabolism*
Proto-Oncogene Proteins c-akt / metabolism*
Receptor Tyrosine Kinase-like Orphan Receptors / antagonists & inhibitors*
Signal Transduction / drug effects
TOR Serine-Threonine Kinases / metabolism*

Substances

Antibodies, Monoclonal
ROR1 protein, human
Receptor Tyrosine Kinase-like Orphan Receptors
Proto-Oncogene Proteins c-akt
TOR Serine-Threonine Kinases