Cytotoxic hydroanthraquinones from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704

Masahiko Isaka; Panida Chinthanom; Pranee Rachtawee; Kitlada Srichomthong; Prasert Srikitikulchai; Palangpon Kongsaeree; Samran Prabpai

doi:10.1038/ja.2014.153

Cytotoxic hydroanthraquinones from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704

J Antibiot (Tokyo). 2015 May;68(5):334-8. doi: 10.1038/ja.2014.153. Epub 2014 Nov 19.

Authors

Masahiko Isaka¹, Panida Chinthanom¹, Pranee Rachtawee¹, Kitlada Srichomthong¹, Prasert Srikitikulchai¹, Palangpon Kongsaeree², Samran Prabpai²

Affiliations

¹ National Center for Genetic Engineering and Biotechnology (BIOTEC), Klong Luang, Pathumthani, Thailand.
² 1] Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Mahidol University, Bangkok, Thailand [2] Center for Excellence in Protein Structure and Function, Faculty of Science, Mahidol University, Bangkok, Thailand.

PMID: 25407145
DOI: 10.1038/ja.2014.153

Abstract

Two new hydroanthraquinones, paradictyoarthrins A (1) and B (2), were isolated from the mangrove-derived fungus Paradictyoarthrinium diffractum BCC 8704. Structures of the new compounds were elucidated by analyses of the NMR spectroscopic and mass spectrometry data. The absolute configuration of 1 was determined by X-ray crystallography. These compounds exhibited cytotoxic activities.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anthraquinones / chemistry*
Anthraquinones / metabolism*
Ascomycota / metabolism*
Ecosystem
Models, Molecular
Molecular Structure

Substances

Anthraquinones