"Clues on Balo's concentric sclerosis evolution from serial analysis of ADC values"

Int J Neurosci. 2016;126(1):88-95. doi: 10.3109/00207454.2014.989524. Epub 2015 Jan 5.

Abstract

Balò's sclerosis is considered a rare variant of multiple sclerosis characterized by demyelination with concentric rings. Advanced magnetic resonance studies allow nowadays early diagnosis and prompt treatment. However, the pathophysiology of lesion evolution is still matter of debate, as detailed in our literature review. Based on a clear-cut Balò's lesion analysis, we describe early changes in DWI and ADC values within the different layers, favoring the concept of a centrifugal growth.

Keywords: ADC; Balò's sclerosis; MRI; concentric sclerosis; diffusion.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Biopsy
  • Brain Edema / etiology
  • Brain Edema / pathology
  • Contrast Media
  • Diffuse Cerebral Sclerosis of Schilder / complications
  • Diffuse Cerebral Sclerosis of Schilder / drug therapy
  • Diffuse Cerebral Sclerosis of Schilder / pathology*
  • Diffusion
  • Diffusion Magnetic Resonance Imaging
  • Disease Progression
  • Gadolinium
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Magnetic Resonance Imaging / methods*
  • Methylprednisolone / therapeutic use
  • Models, Neurological
  • Neuroimaging / methods*
  • Oligodendroglia / pathology
  • Organometallic Compounds
  • White Matter / pathology

Substances

  • Contrast Media
  • Immunosuppressive Agents
  • Organometallic Compounds
  • gadobutrol
  • Gadolinium
  • Methylprednisolone