Psychometrics evaluation of Charcot-Marie-Tooth Neuropathy Score (CMTNSv2) second version, using Rasch analysis

Reza Sadjadi; Mary M Reilly; Michael E Shy; Davide Pareyson; Matilde Laura; Sinead Murphy; Shawna M E Feely; Tiffany Grider; Chelsea Bacon; Giuseppe Piscosquito; Daniela Calabrese; Ted M Burns

doi:10.1111/jns.12084

Psychometrics evaluation of Charcot-Marie-Tooth Neuropathy Score (CMTNSv2) second version, using Rasch analysis

J Peripher Nerv Syst. 2014 Sep;19(3):192-6. doi: 10.1111/jns.12084.

Authors

Reza Sadjadi¹, Mary M Reilly, Michael E Shy, Davide Pareyson, Matilde Laura, Sinead Murphy, Shawna M E Feely, Tiffany Grider, Chelsea Bacon, Giuseppe Piscosquito, Daniela Calabrese, Ted M Burns

Affiliation

¹ Department of Neurology, University of Virginia, Charlottesville, VA, USA.

Abstract

Charcot-Marie-Tooth Neuropathy Score second version (CMTNSv2) is a validated clinical outcome measure developed for use in clinical trials to monitor disease impairment and progression in affected CMT patients. Currently, all items of CMTNSv2 have identical contribution to the total score. We used Rasch analysis to further explore psychometric properties of CMTNSv2, and in particular, category response functioning, and their weight on the overall disease progression. Weighted category responses represent a more accurate estimate of actual values measuring disease severity and therefore could potentially be used in improving the current version.

Keywords: Charcot-Marie-Tooth; Charcot-Marie-Tooth Neuropathy Score (CMTNS2) second version; Rasch analysis; outcome measures; psychometrics.

Publication types

Evaluation Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Charcot-Marie-Tooth Disease / diagnosis*
Disease Progression*
Humans
Psychometrics / instrumentation*
Severity of Illness Index*

Abstract

Publication types

MeSH terms

Grants and funding